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KMID : 0376419960200010011
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Chonbuk University Medical Journal
1996 Volume.20 No. 1 p.11 ~ p.20
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A Morphologic Study of Fat Storing Cell in Acute Liver Injury
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문우성
강명재/이동근/최호열/김상호
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Abstract
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The present study was undertaken to investigate the role of fat storing cell(FSC) in ICR mice with acute liver injury induced by intraperitoneal injection of carbon tetrachloride, using light and electron microscopy. During the first two days
after
poisoning, centrilobular necrosis and proliferation of FSCs were most prominent. From the 3rd day onward, extracellular collagen fibers increased gradually. Ultrastructually, proliferated FSC contained well developed rough endoplasmic reticulum
(rEr)
and a small amount of lipid droplets with a mitochondria, and typical collagen fibrils were frequently seen in close proximity to these cells the fifth day. This study suggest that fibrosis in the acutely damaged liver is due to connective tissue
synthesis by the activation of FSC and the FSC is the precursor of the fibroblast.
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KEYWORD
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